Archives: Projects/Publication

Increased-Resolution OCT Thickness Mapping of the Human Macula: A Statistically Based Registration.

Bernardes R., Santos T., Cunha-Vaz J.

Purpose: To describe the development of a technique that enhances spatial resolution of retinal thickness maps of the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). A retinal thickness atlas (RT-atlas) template was calculated, and a macular coordinate system was established, to pursue this objective.

Methods: The RT-atlas was developed from principal component analysis of retinal thickness analyzer (RTA) maps acquired from healthy volunteers. The Stratus OCT radial thickness measurements were registered on the RT-atlas, from which an improved macular thickness map was calculated. Thereafter, Stratus OCT circular scans were registered on the previously calculated map to enhance spatial resolution.

Results: The developed technique was applied to Stratus OCT thickness data from healthy volunteers and from patients with diabetic retinopathy (DR) or age-related macular degeneration (AMD). Results showed that for normal, or close to normal, macular thickness maps from healthy volunteers and patients with DR, this technique can be an important aid in determining retinal thickness. Efforts are under way to improve the registration of retinal thickness data in patients with AMD.

Conclusions. The developed technique enhances the evaluation of data acquired by the Stratus OCT, helping the detection of early retinal thickness abnormalities. Moreover, a normative database of retinal thickness measurements gained from this technique, as referenced to the macular coordinate system, can be created without errors induced by missed fixation and eye tilt.

Invest. Ophthalmol. Vis. Sci; 2008; 49 (5): 2046-2052.

2008
http://www.iovs.org/cgi/reprint/49/5/2046

Perspectives for multimodal imaging of the retina in disease.

Bernardes R., Cunha-Vaz J.

8th EURETINA Congress, Vienna, Austria, May 22-25, 2008, 1:15-1:17.

2008

Method and apparatus for measuring quantity of a fluorochrome in a biological environment.

Schwartz A., Bernardes R., Franke S., Morgado A.

World Intellectual Property Organization. WO 2008/067525 A2, 5 de Julho de 2008.

2008

Desenvolvimento de Novas Metodologias para o Mapeamento Multimodal da Mácula

Bernardes R.

PhD Tesis, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2008.

2008

Multimodal mapping of the macula.

Bernardes R., Lobo C., Cunha-Vaz J.

Ophthalmol. Intern., Summer 2008; 3 (2): 58-61.

2008