Archives: Projects/Publication

Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel.

Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel.

Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel.

AF Macedo, FB Marques, CA Fontes Ribeiro, F Teixeira

Pharmacoepidemiol. Drug Saf. 14(12): 885 – 890, 2005

2005

Single or Multiple Injections of Metamphetamine Increased Dopamine Turnover but Did Not Decrease Tyrosine Hydroxylase Levels or Cleave Caspase-3 in Caudate-Putamen

Single or Multiple Injections of Metamphetamine Increased Dopamine Turnover but Did Not Decrease Tyrosine Hydroxylase Levels or Cleave Caspase-3 in Caudate-Putamen

Single or Multiple Injections of Metamphetamine Increased Dopamine Turnover but Did Not Decrease Tyrosine Hydroxylase Levels or Cleave Caspase-3 in Caudate-Putamen

F. C. Pereira, E. S. Lourenço, F. Borges, T. Morgadinho, C. A. Fontes Ribeiro, T. R. Macedo, S. F. Ali.

Synapse, 60: 185 – 193, 2006

2006

Can Decisional Algorithms Replace Global Introspection in the Individual Causality Assessment of Spontaneously Reported ADRs?

Can Decisional Algorithms Replace Global Introspection in the Individual Causality Assessment of Spontaneously Reported ADRs?

Can Decisional Algorithms Replace Global Introspection in the Individual Causality Assessment of Spontaneously Reported ADRs?

AF Macedo, FB Marques, CA Fontes Ribeiro

Drug Safety. 29(8):697-702, 2006

2006

Methamphetamine, Morphine, and Their Combination: Acute Changes in Striatal Dopaminergic Transmission Evaluated by Microdialysis in Awake Rats

Methamphetamine, Morphine, and Their Combination: Acute Changes in Striatal Dopaminergic Transmission Evaluated by Microdialysis in Awake Rats

Methamphetamine, Morphine, and Their Combination: Acute Changes in Striatal Dopaminergic Transmission Evaluated by Microdialysis in Awake Rats

FC Pereira, E Lourenço, N Milhazes, T Morgadinho, C A Fontes Ribeiro, Syed F Ali, T R Macedo

Ann NY Acad Sci 1074: 160–173, 2006

2006

Electromyographyc analysis of an abdominal exercise performed in trained and untrained subjects

Electromyographyc analysis of an abdominal exercise performed in trained and untrained subjects

Electromyographyc analysis of an abdominal exercise performed in trained and untrained subjects

P Tavares , E Ribeiro, M Marcelino, G Fontes Ribeiro, F Rosado and C. A. Fontes Ribeiro

Journal of the Coimbra Network of Exercise Sciences, 3(1): 55 – 59, 2006. (Ediction online of: Journal of the Coimbra Network of Exercise Sciences, 2006).

2006

Pre- and postjunctional effects of ATP and NPY on sympathetic control of human uterine artery

Pre- and postjunctional effects of ATP and NPY on sympathetic control of human uterine artery

Pre- and postjunctional effects of ATP and NPY on sympathetic control of human uterine artery

C. Cavadas, C.A. Fontes Ribeiro, C. Neta, J. Silva, S. Gulbenkian, M.T. Morgadinho, S.A.R. Silva, T.R.A Macedo

Poster with oral discussion in 3th Meeting of the Portuguese Society for Neuroscience (Espinho, December de 1996)

1996

Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Luis Almeida, Amílcar Falcão, Manuel Vaz-da-Silva, Teresa Nunes, Ana-Teresa Santos, José-Francisco Rocha, Carla Neta, Tice Macedo, C. Fontes-Ribeiro and P. Soares-da-Silva

Abstract

Objective  Nebicapone is a new catechol-O-methyltransferase inhibitor. In vitro, nebicapone has showed an inhibitory effect upon CYP2C9, which is responsible for the metabolism of S-warfarin. The objective of this study was to investigate the effect of nebicapone on warfarin pharmacokinetics and pharmacodynamics in healthy subjects.

Methods  Single-centre, open-label, randomised, two-period crossover study in 16 healthy volunteers. In one period, subjects received nebicapone 200 mg thrice daily for 9 days and a racemic warfarin 25-mg single dose concomitantly with the nebicapone morning dose on day 4 (test). In the other period, subjects received a racemic warfarin 25-mg single dose alone (reference). The treatment periods were separated by a washout of 14 days.

Results  For R-warfarin, mean ± SD Cmax was 1,619 ± 284 ng/mL for test and 1,649 ± 357 ng/mL for reference, while AUC0-t was 92,796 ± 18,976 ng·h/mL (test) and 73,597 ± 11,363 ng·h/mL (reference). The R-warfarin test-to-reference geometric mean ratio (GMR) and 90% confidence interval (90%CI) were 0.973 (0.878–1.077) for Cmax and 1.247 (1.170–1.327) for AUC0-t . For S-warfarin, mean ± SD Cmax was 1,644 ± 331 ng/mL for test and 1,739 ± 392 ng/mL for reference, while AUC0-t was 66,627 ± 41,199 ng·h/mL (test) and 70,178 ± 42,560 ng·h/mL (reference). The S-warfarin test-to-reference GMR and 90%CI were 0.932 (0.845–1.028) for Cmax and 0.914 (0.875–0.954) for AUC0-t . No differences were found for the pharmacodynamic parameter (INR).

Conclusion  Nebicapone showed no significant effect on S-warfarin pharmacokinetics or on the coagulation endpoint (INR). A mild inhibition of the R-warfarin metabolism was found but is unlikely to be of clinical relevance

Eur J Clin Pharmacol(October, 2008-Volume 64, Number 10 )

2008
http://www.springerlink.com/content/m3617087h1347604/