Financiamento da Inovação em Oncologia
Financiamento da Inovação em Oncologia
Gouveia Pinto C, Varela C, Batel Marques F, Oliveira J, Espírito Santo J, Aranda da Silva J, Pazos MI, Gouveia M, Miranda N
Rev Port Farmacoter 2015; 7: 54-57
2015
Drug-induced ocular adverse reactions: review of the safety alerts issued during the last decade
Drug-induced ocular adverse reactions: review of the safety alerts issued during the last decade
Penedones A, Mendes D, Alves C, Batel Marques F
J Ocul Pharmacol Ther. 2015 Jun;31(5):258-68.
2015
http://www.ncbi.nlm.nih.gov/pubmed/25871404
Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit
Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit
Batel Marques F, Mendes D, Alves C, Penedones A, Dias P, Martins A, Santiago LM, Fontes-Ribeiro C, Caramona M, Macedo T
Acta Med Port 2015 Mar-Apr; 28(2):222-232
2015
http://www.ncbi.nlm.nih.gov/pubmed/?term=Pharmacovigilance+in+Portugal%3A+Activity+of+the+Central+Pharmacovigilance+Unit
The role of Disproportionality Analysis of Pharmacovigilance Databases in Safety Regulatory Actions: a Systematic Review
The role of Disproportionality Analysis of Pharmacovigilance Databases in Safety Regulatory Actions: a Systematic Review
Dias P, Penedones A, Alves C, Fontes Ribeiro C, Batel Marques F
Current Drug Saf. 2015, 10(2): 000-000
2015
http://www.ncbi.nlm.nih.gov/pubmed/?term=The+role+of+Disproportionality+Analysis+of+Pharmacovigilance+Databases+in+Safety+Regulatory+Actions%3A+a+Systematic+Review
Pharmacies and the Economic Crisis in Portugal: A Case-Study
Pharmacies and the Economic Crisis in Portugal: A Case-Study
Aguiar AH, Martins L, Batel Marques F
Inernational Journal of Health Sciences June 2015, Vol. 3 , No. 2, pp. 43-47.
2015
Number needed to harm in the post-marketing safety evaluation: results for rosiglitazone and pioglitazone
Number needed to harm in the post-marketing safety evaluation: results for rosiglitazone and pioglitazone
Mendes D, Alves C, Batel Marques F
Pharmacoepidemiol Drug Saf. 2015 Sep 16. doi: 10.1002/pds.3874.
2015
http://www.ncbi.nlm.nih.gov/pubmed/26376779
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection.
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection.
Santos-Carvalho A., Álvaro A., Martins J., Ambrósio A., Cavadas C.
Neuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca(2+)]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets.
Prog Neurobiol., 2014, 112, 70-79. doi:10.1016/j.pneurobio.2013.10.002
2014
Ocular Fundus Reference Images from Optical Coherence Tomography.
Ocular Fundus Reference Images from Optical Coherence Tomography.
Guimarães P., Rodrigues P., Lobo C., Leal S., Figueira J., Serranho P., Bernardes R.
Computerized Medical Imaging and Graphics (CMIG), 2014, 38(5), 381-389. doi:10.1016/j.compmedimag.2014.02.003
2014
Unveiling preclinical idiopathic macular hole formation using support vector machines.
Unveiling preclinical idiopathic macular hole formation using support vector machines.
Silva A., Figueira J., Simão S., Gomes N., Neves C., Meireles A., Ferreira N., Bernardes R.
Macular holes are ruptures in the central part of the retina that if left untreated may lead to serious vision loss. Although there is a lot yet to know about this pathology, it is established that if one suffers from unilateral idiopathic macular hole (IMH), then there is an increased risk of developing the same condition in the fellow eye. The goal of this work is to use optical coherence tomography (OCT) scans and, resorting to automatic pattern recognition algorithms, develop a classifier that distinguishes eyes at risk of developing IMH from healthy controls. From the collected data we were able to estimate a set of parameters that allow for the classification of eyes into the group of eyes at risk or healthy controls with an accuracy of 95.1%, sensitivity of 96.9% and specificity of 93.1%.
IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), 2014, 585-588. doi:10.1109/BHI.2014.6864432.
2014
Monte Carlo Simulation of Diabetic Macular Edema Changes on Optical Coherence Tomography Data
Monte Carlo Simulation of Diabetic Macular Edema Changes on Optical Coherence Tomography Data
Correia A., Pinto L., Araujo A., Barbeiro S., Caramelo F., Menezes P., Morgado M., Serranho P., Bernardes R.
IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), 2014, 724-727. doi:10.1109/BHI.2014.6864466.
2014
