AIBILI-Association for Innovation and Biomedical Research on Light and Image

MACUSTAR: Development and clinical validation of functional, structural and patient-reported endpoints in intermediate age-related macular degeneration

Robert P. Finger, Steffen SchmitzValckenberg, Matthias Schmid, Gary S. Rubin, Hannah Dunbar, Adnan Tufail, David P. Crabb, Alison Binns, Clara I. Sánchez, Philippe Margaron, Guillaume Normand, Mary Durbin, Ulrich Luhmann, Parisa Zamiri, José Cunha-Vaz, Friedrich Asmus, Frank G. Holz, Jan Henrik Terheyden

Ophthalmologica. 2019;241(2):61-72. doi: 10.1159/000491402. Epub 2018 Aug 28. Review.

2019

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population.

Mauschitz M, Bonnemaijer P, Diers K, Rauscher F, Elze T, Engel C, Loeffler M, Colijn J, Ikram MA, Vingerling J, Williams K, Hammond C, Creuzot-Garcher C, Bron A, MD, Silva R, Nunes S, Delcourt C, Cougnard-Grégoire A, Holz F, Klaver C, Breteler M, Finger R, on behalf of the European Eye Epidemiology(E3) Consortium.

Ophthalmology. 2018 Apr 28. pii: S0161-6420(17)33477-2. doi: 10.1016/j.ophtha.2018.03.026

2018

Changes in intraocular pressure after intravitreal fluocinolone acetonide (ILUVIEN): real-world experience in three European countries

Usha Chakravarthy, Simon R Taylor, Frank H Johannes Koch, João Paulo Castro de Sousa, Clare Bailey

Br J Ophthalmol 2018;0:1-doi.org/10.1136/bjophthalmol-2018-312284

2018

Methodologic assessment of the systematic reviews of ophthalmic adverse drug reactions published in Ophthalmology journals: a systematic review

Penedones A, Batel-Marques F

PURPOSE:

This systematic review aims to characterize and review the methodology of the systematic reviews reporting ophthalmic adverse drug reactions.

METHODS:

This systematic review followed the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-analyses guide. MEDLINE and EMBASE databases were searched, by all Ophthalmology journals. All systematic reviews reporting ophthalmic adverse drug reactions in the last decade were included. Data on methodology were extracted. Methodological quality was assessed through A MeaSurement Tool to Assess systematic Reviews 2 scale. Descriptive analysis was performed.

RESULTS:

Twenty-one systematic reviews were identified. Almost 60% of the systematic reviews reported non-ophthalmic drugs. Nine (43%) systematic reviews did not follow any recommendation. A search filter was not applied in 48% systematic reviews. Observational data was the source of information most included. The methodological quality was assessed in 57% systematic reviews. A meta-analysis was performed in 57% systematic reviews. The protocol’s elaboration, the explanation of the sources of information and the list of excluded articles were the domains less performed in the systematic reviews.

CONCLUSION:

The systematic reviews reporting ophthalmic adverse drug reactions diverged in some methodological aspects. Such an issue deserves further investigation, since discrepancies may lead to biased conclusions and, consequently, impact clinical and/or regulatory decisions.

Ophthalmic Res. 2018;60(2):55-68. doi: 10.1159/000489932.

2018
https://www.ncbi.nlm.nih.gov/pubmed/29975961

Drug-induced hypersensitivity: a 5-year retrospective study in a hospital electronic health records database

Mendes D, Alves C, Loureiro M, Fonte A, Batel Marques F

Journal of Clinical Pharmacy and Therapeutics

2018

Noninvasive Multimodal Imaging of Diabetic Retinopathy.

Marques I, Mendes L, Cunha-Vaz J

In: Imaging Techniques. ESASO Course Series. Cunha-Vaz J, Koh A (eds): Basel, Karger, 2018, vol 10, pp 88-101. https://doi.org/10.1159/000487414

2018

Quantification of Retinal Microvascular Density in Optical Coherence Tomography Angiography Images in Diabetic Retinopathy.

Durbin MK, An L, Shemonski DS, Soares M, Santos T, Lopes M, Neves C, Cunha-Vaz J.

JAMA Ophthalmol. 2017;135(4):370-376.

2017

OCT-Leakage mapping. A new automated method of OCT data analysis to identify and locate abnormal fluid in retinal edema

Farinha C, Santos T, Marques IP, Marques JP, Ribeiro L, Figueira J, Silva R, Cunha-Vaz J

Ophthalmology Retina 2017;1:486-496.

2017

Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Project.

Santos AR, Ribeiro L, Bandello F, Lattanzio R, Egan C, Frydkjaer-Olsen U, García-Arumí J, Gibson J, Grauslund J, Harding SP, Lang GE, Massin P, Midena E, Scanlon P, Aldington SJ, Simão S, Schwartz C, Ponsati B, Porta M, Costa MÂ, Hernández C, Cunha-Vaz J, Simó R; European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR).

Diabetes. 2017 Sep;66(9):2503-2510.

2017

Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study).

Figueira J, Fletcher E, Massin P, Silva R, Bandello F, Midena E, Varano M, Sivaprasad S, Eleftheriadis H, Menon G, Amaro M, Ayello Scheer S, Creuzot-Garcher C, Nascimento J, Alves D, Nunes S, Lobo C, Cunha-Vaz J; EVICR.net Study Group.

Ophthalmology. 2018 May;125(5):691-700.

2018

Quantification of Retinal Microvascular Density in Optical Coherence Tomography Angiography Images in Diabetic Retinopathy

DurbinMK, An L, Shemonski DS, Soares M, Santos T, Lopes M, Neves C, Cunha-Vaz J.

JAMA Ophthalmol. 2017;135(4):370-376

2017

OCT_Leakage mapping. A new automated method of OCT data analysis to identify and locate abnormal fluid in retinal edema

Farinha C, Santos T, Marques IP, Marques JP, Ribeiro L, Figueira J, Silva R, Cunha-Vaz J

Ophthalmology Retina 2017;1:486-496

2017

The Blood- Retinal Barrier in the Management of Retinal Disease: EURITINA Award Lecture

Cunha-Vaz J

Ophthalmologica 2017;237(1):1-10

2017

Calcium Dobesilate is Protective against Inflammation and Oxidative/Nitrosative Stess in the Retina of aType 1 Diabetic Rat Model

Paula Voabil, Joana Liberal, Ermelindo C. Leal, Jaques Bauer, José Cunha-Vaz, Ana Raquel Santiago, António Francisco Ambrósio

Ophthalmic Research 2017 DOI:10.1159/000478784

2017

Multimodal Evaluation of the Fellow Eye of Patients With Retinal Angiomatous Proliferation

Martins A, Farinha C, Raimundo M, Neves C, Lopes M, Melo P, Barreto P, Marques M, Cachulo ML, Marques JP, Cunha-Vaz J, Silva R

Ophthalmic Res. 2018;59(2):88-97.

2018

Changes in Reticular Pseudodrusen Area in eyes that Progressed from early to late Age-related Macular Degeneration

Kaszubski PA, Ben Ami T, Saade C, Nabati C, Kumar V, Santos AR, Silva R, Cachulo ML, Cunha-Vaz JG, Smith RT

Int Ophthalmol. DOI 10.1007/s10792-017-0485-7 Published online: 07 March 2017

2017

Early persistent retinal fluid during treatment of neovascular AMD with ranibizumab and aflibercept.

Marques JP, Cunha-Vaz J

Journal of Xiangya Medicine 2017; 2:51

2017

A New Automed method of OCT Data Analysis to Identify and Locate Abnormal Fluid in Retinal Edema.

Cláudia Farinha, Torcato Santos, Inês P. Marques, João P. Marques, Luísa Ribeiro, João Figueira, Rufino Silva, José Cunha-Vaz

American Academy Ophthalmology http://dx.doi.org/10.1016/joret2017.03.004

2017

Prevalence of Age-related Macular Degeneration in Europe: the past and the future

Johanna M. Colijn ; Gabriëlle H.S. Buitendijk; Elena Prokofyeva; Dalila Alves; Cachulo ML; Anthony P. Khawaja; Audrey Cougnard-Gregoire, Stefan Nickels, Maja G Erke, Alain Bron, Magda A. Meester-Smoor; EYE-RISK consortium; Catherine Creuzot-Garcher; Geir Bertelsen1; Norbert Pfeiffer; Astrid Fletcher; Paul J Foster; Rufino Silva; Cecile Delcourt;, Caroline C.W. Klaver; for the European Eye Epidemiology (E3) Consortium

Ophthalmology 10.1016/j.ophtha.2017.05.035 (Available online 14 July 2017)

2017
https://doi.org/10.1016/j.ophtha.2017.05.035

Prevalence of Age-related Macular Degeneration in Europe: the past and the future

Ophthalmology 10.1016/j.ophtha.2017.05.035 (Available online 14 July 2017)

2017
https://doi.org/10.1016/j.ophtha.2017.05.035