AIBILI-Association for Innovation and Biomedical Research on Light and Image

Khawaja1 AP, Springelkamp H, Creuzot-Garcher C, Delcourt C, Hofman A, Höhn R, Iglesias AI, Wolfs RCW, Jean-François Korobelnik, Silva R, Topouzis F, Williams KM, Bron AM, Buitendijk GHS, da Luz Cachulo M, Cougnard-Gregoire A, Jean-François Dartigues, Hammond C, Pfeiffer N, Salonikiou A, van Duijn CM, Vingerling JR, Luben RN, Mirshahi A, Lamparter J, Klaver CCW, Jansonius NM, Foster PJ, On behalf of the European Eye Epidemiology (E3) Consortium.

Eur J Epidemiol DOI 10.1007/s10654-016-0191-1

2016

Vision related quality of life in patients with type 2 diabetes in the EUROCONDOR trial

Trento M, Durando O, Lavecchia S, Charrier L, Cavallo F, Costa MA, Hernández C, Simó R, Porta M, for the EUROCONDOR trial investigators.

Endocrine DOI 10.1007/s12020-016-1097-0
2016

Testing the usefulness of the number needed to treat to be harmed (NNTH) in benefit-risk evaluations: case study with medicines withdrawn from the European market due to safety reasons.

Mendes D, Alves C, Batel Marques F.

OBJECTIVE:

To explore the usefulness of number needed to treat to be harmed (NNTH), in benefit-risk assessments, by studying the agreement between NNTH values and withdrawals of medicines from European market due to safety reasons.

METHODS:

Medicines with data from longitudinal studies were included. Studies were identified from European Medicines Agency’s Reports. Meta-analyses were performed to pool odds ratios (OR) with 95% confidence-intervals (CI). Published control event rates were applied to ORs to calculate NNTHs (95%CI) for selected adverse events.

RESULTS:

NNTH (95%CI) decreased from pre- to post-marketing for the eight medicines included: peripheral neuropathy (∞ vs. 12[non-significant; NS] with almitrine; heart valve disease with benfluorex (∞ vs. NNTH ranging from 7[4-13] to 7[5-9]); myopathy (-4096[NS] vs. 797[421-1690]), new-onset diabetes (113[NS] vs. 390[425-778]), bleeding (∞ vs. 517[317-1153]), and infection (∞ vs. 253[164-463]) with niacin-laropiprant; psychiatric disorders (12[7-34] vs. 9[5-24]) with rimonabant; myocardial infarction (MI) [-1305 vs. 270[89-4362]) with rofecoxib; MI (-510 vs. NNTH ranging from 152[55-4003] to 568[344-1350]) with rosiglitazone; cardiovascular events (∞ vs. 245[129-1318]) with sibutramine; and liver injury (∞ vs. 5957[NS]) with ximelagatran.

CONCLUSION:

NNTH have potential of use as a supportive tool in benefit-risk re-evaluations of medicines and may help regulators to making decisions on drug safety.

Expert Opin Drug Saf. 2016 Jul 28;15(10):1301-12. doi: 10.1080/14740338.2016.1217989

2016
http://www.ncbi.nlm.nih.gov/pubmed/27467204

Risk of Ophthalmic Adverse Effects in Patients Treated with MEK Inhibitors: A Systematic Review and Meta-Analysis

Alves C, Ribeiro I, Penedones A, Mendes D, Batel Marques F

Ophthalmic Res. 2016 Jul 13;57(1):60-69. DOI:10.1159/000446845

2017
https://www.karger.com/Article/Abstract/446845

Drug Transport Across Blood-Ocular Barriers and Pharmacokinetics

Cunha-Vaz J, Batel Marques F, Fernandes R, Alves C, Velpandian T

Pharmacology of Ocular Therapeutics, Edition: 1st, Chapter: 3. Drug Transport Across Blood-Ocular Barriers and Pharmacokinetics, Publisher: Springer International, Editors: Thirumurthy Velpandian, pp.37-63

2016

Comparison of preservative – free latanoprost and bimatoprost in a multicenter, randomized, investigator – masked cross- over clinical trial, the SPORT trial

Stalmans I, Oddone F, Cordeiro MF, Hommer A, Montesano G, Ribeiro L, Mégevand GS, Rossetti L for the EVICR.net.

Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-016-3299-9

2016

Age-related Macular Degeneration in Portugal: prevalence and risk factors in a coastal and an inland town. The Coimbra Eye Study Report 2

M. Cachulo, I. Laíns, C. Lobo, J. Figueira, L. Ribeiro, J. P. Marques, J. Costa, A. Vieira, J. Rodrigues, D. Alves, S. Nunes, M. Costa, V. Rodrigues, J. Cunha-Vaz, C. Delcourt, R. Silva

Acta Ophthalmol. 2016 Sep;94(6):e442-53. doi: 10.1111/aos.12950.

2016

A systematic review and meta-analysis of the association between systemic fluoroquinolones and retinal detachment.

Carlos Alves, Ana Penedones, Diogo Mendes and Francisco Batel Marques

Acta Ophthalmol. 2016 Feb 5. doi: 10.1111/aos.12931.

2016
http://onlinelibrary.wiley.com/doi/10.1111/aos.12931/abstract;jsessionid=0857755765BEDB9128402C8C786E8567.f01t02

Simulation of Cellular Changes on Optical Coherence Tomography of Human Retina

M. Santos, A. Araújo, S. Barbeiro, F. Caramelo, A. Correia, M. Marques, L. Pinto, P. Serranho, R. Bernardes, M. Morgado

Engineering in Medicine and Biology Society (EMBC), 37th Annual International Conference of the IEEE (2015), 8147-8150, DOI: 10.1109/EMBC.2015.7320285

2015

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

M. Madeira, F. Elvas, R. Boia, F. Gonçalves, R. Cunha, A. Ambrósio, A. Santiago

Journal of Neuroinflammation (2015) 12:115 DOI 10.1186/s12974-015-0333-5

2015