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CORC // Coimbra Ophthalmology Reading Centre

Progression of Diabetic Retinopathy. Identification of Signs and Surrogate outcomes. (PROGRESS, Protocol CEC/007/16) [more info]

A Phase 2, single-masked, multicentre study to evaluate the safety and efficacy of 2 dose levels of THR-317 for the treatment of diabetic macular oedema (DME). (Protocol THR-317-001) [more info]

Exploratory analysis on the correlation of Fluorescein Angiography images and OCT-Leakage. [more info]

OCT-A (Optical Coherence Tomography Angiography): Evaluation and Comparison with FA. [more info]

AMD Incidance Central Portugal - Coimbra Eye Study: The five-year incidence of Age-Related Macular Degeneration. A clinical study with color fundus photography, optical coherence tomography and blood sample collection in Mira. (AMD Incidence_CPT, Protocol 4C-2016-09) [more info]

An open-label, randomized, active-controlled, parallel-group, Phase-3b study of the efficacy, safety, and tolerability of three different treatment regimens of 2 mg Eylea administered by intravitreal injections to subjects with diabetic macular edema (DME). (VIOLET, Protocol BAY 86-5321 / 17613) [more info]

An open-label, randomized, active-controlled, parallel-group, Phase-3b study of the efficacy, safety, and tolerability of 2 mg aflibercept administered by intravitreal injections using two different treatment regimens to subjects with neovascular age-related macular degeneration (nAMD). (AZURE, Protocol BAY 86-5321 / 16598) [more info]

Open-label Phase-4 study to examine the change of vision-related quality of life in subjects with diabetic macular edema (DME) during treatment with intravitreal injections of 2 mg aflibercept according to EU label for the first year of treatment. (AQUA, Protocol BAY 86-5321 /17850) [more info]

A Randomized, Double-masked, Sham-controlled Phase 4 Study of the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in patients with Polypoidal Choroidal Vasculopathy. (ATLANTIC, Protocol ECR-AMD-2015-09) ) [more info]

DR Screening - central reading for pilot studies for Critical Health. [more info]

Prospective, randomized, multicentre, open label, phase II / III study to assess efficacy and safety of ranibizumab 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP in monotherapy in the treatment of subjects with high risk proliferative diabetic retinopathy. (PROTEUS, Protocol ECR-RET-2013-05) [more info]

Neurodegeneration as an early event in the pathogenesis of Diabetic Retinopathy: A multicentric, prospective, phase II-III, randomised controlled trial to assess the efficacy of neuroprotective drugs administered topically to prevent or arrest Diabetic Retinopathy (EUROCONDOR, Protocol nº 4C-2011-02) [more info]

Diabetic Retinopathy Screening – Central Region of Portugal [more info]


  • Grading of ophthalmic exams for characterization and quantification of ophthalmic disease

               Grading of fundus images
               Grading OCT
               Grading mfERG

  • Project management and acquisition and grading protocol development
  • Technicians training and certification
  • Equipment certification
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