Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Luis Almeida & Amílcar Falcão & Manuel Vaz-da-Silva & Teresa Nunes & Ana-Teresa Santos & José-Francisco Rocha & Carla Neta & Tice Macedo & C. Fontes-Ribeiro & P. Soares-da-Silva

ABSTRACT
Objective: Nebicapone is a new catechol-O-methyltransferase inhibitor. In vitro,
nebicapone showed an inhibitory effect upon CYP2C9, which is responsible for the
metabolism of S-warfarin. The objective of this study was to investigate the effect of
nebicapone on the warfarin pharmacokinetics and pharmacodynamics in healthy
subjects.

Eur J Clin Pharmacol, 64: 961 – 966, 2008.

2008