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4C // Coimbra Coordinating Centre for Clinical Research

Characterization of Retinal vascular disease in eyes with mild to moderate NPDR in Diabetes type 2, using novel non-invasive Imaging methods, in a longitudinal and prospective clinical Study with 2 years of duration. (CORDIS, Protocol CEC010/2018) [more info]

Progression of Diabetic Retinopathy. Identification of Signs and Surrogate outcomes. (PROGRESS, Protocol CEC/007/16) [more info]

Characterization of potential biomarkers of Eye Disease and Vision Loss (EyeMarker). [more info]

Apoio na análise de dados e na elaboração de trabalhos científicos para estudos observacionais/retrospetivos da AIBILI/CHUC. (STAT) [more info]

Five-year incidence of Age-related Macular Degeneration in the central region of Portugal (AMDIncidence_CPT) [more info]

A multi-center randomized, placebo-controlled trial of mirabegron, a new beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease (BETA3) [more info]

The longitudinal observational early markers study (LOBS) [more info]

A Randomized, Double-masked, Sham-controlled Phase 4 Study of the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in patients with Polypoidal Choroidal Vasculopathy (ATLANTIC). Protocol ECR-AMD-2015-09 [more info]

E3 Consortium to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe. E3 [more info]

An open label, registry study of the safety of ILUVIEN® fluocinoloneacetonide 190 micrograms intravitreal implant in applicator (IRISS). Protocol M-01-12-001 [more info]


  • Investigator-driven clinical trials (IDCTs) support
  • Study documents elaboration
  • Submission to the regulatory authorities
  • Data Management
  • Education and Training
  • Regulatory issues
  • Statistical analysis
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