CNTM

The Centre for New Technologies in Medicine (CNTM) develops new medical diagnostic techniques with special emphasis on the area of eye fundus imaging.

SERVICES
  • Development of non-invasive, methodologies for OCT measurement
  • Multimodal Macular Mapping
  • Automatic analysis of medical images
  • Artificial intelligence for characterization of retinal biomarkers

The Centre for New Technologies in Medicine (CNTM) develops new medical diagnostic techniques with special emphasis on the area of eye fundus imaging.

The eye offers unique opportunities to obtain in a non-invasive manner information on the body, in general and of the retina and brain in particular. It is, in fact, a window to the body.

CNTM is particularly interested in developing non-invasive methodologies that allow repeated observations and measurements in order to identify early alterations that may allow timely therapeutic interventions, e.g., precision medicine.

CNTM has been able to patent novel biomarkers of disease progression, such as microaneurysm turnover in diabetic retinopathy identified automatically by software developed in-house, the Retmarker®, developed in a partnership with Retmarker SA., and fluid quantification in the retinal diseases by identifying non-invasively changes in the Blood-Retinal Barrier in the retina, using a novel algorithm, the OCT-Leakage. CNTM is also engaged with EVICR.net in the development of the EVICR.net Eye Platform. This platform, composed of several components and microservices, will explore the Cloud computing capabilities for gathering high-quality ophthalmology data generated in Europe to allow the re-use of data and foster clinical research.

OCT-L – Patents: EP 3 289 565 B1 | US 11,234,591 B2

Retmarker – US 7,856,135 B1

A major effort is also being made in the validation and development of Optical Coherence Tomography Angiography for diagnosing progression of diabetic retinopathy and to develop methods involving artificial intelligence.

Areas of expertise

  • Development of non-invasive, methodologies for the measurement of Blood-Retinal Barrier (BRB) permeability and vascular occlusion in the human retina based on Optical Coherence Tomography

 

  • Multimodal Macular Mapping. The gathering of information obtained through various imaging techniques in order to establish a correlation between various parameters of the retina providing this way a global vision of the ongoing alterations as well as its space-time relation

 

  • Automatic analysis of medical images. The application of the most recent processing/analytical techniques of medical images to the various types of eye fundus imaging, offers new perspectives on the subject, facilitating registration and follow-up in the daily medical practice
  • Clients

    ‣ Allergan

    ‣ Amsterdam Medical Center

    ‣ Bial

    ‣ OM Pharma

    ‣ Oystershell

    ‣ Pfizer

    ‣ RETMARKER

    ‣ Roche

    ‣ Talia Technology

    ‣ ZEISS Meditec