The Coimbra Ophthalmology Reading Center (CORC) focus its activities in grading fundus images and OCT images of the retina, as well as functional evaluations of the retina using mfERG.
It serves as central Reading Center for a series of clinical trials, mainly in Diabetic Retinopathy (DR) and Age-related Macular Degeneration (AMD).
CORC is also the central Reading Center for the Diabetic Retinopathy Screening Programme of the Central Region of Portugal since 2011.
CORC has dedicated staff composed by the CORC Director, a Management Team involving Project Managers, Grading Supervisors and an Administrative Coordinator, a Grading Team of 22 graders (12 medical graders, 4 orthoptist graders and 6 technical graders) and a Secretariat Team involving general secretariat and study coordinators.
CORC is certified, since 2013, according to the international standard ISO 9001 - Requirements of a Quality Management System for the activity of Grading of Eye Exams.
CORC activities are performed in accordance with internal Standard Operating Procedures (SOPs) which are elaborated in compliance with the ICH Guidelines for Good Clinical Practice (ICH-GCP) and ISO 9001.
Information Technology Systems
CORC has a secure custom-designed web based tool to transmit images between Clinical Sites and CORC.
For grading purposes CORC uses licensed software from the equipment suppliers, such as Cirrus HD-OCT (Carl Zeiss Meditec), Heidelberg Eye Explorer (Heidelberg Engineering), RETIsystem (Roland Consult), Topcon 3D-OCT (Topcon Coorporation), etc.
For research purposes CORC also has novel software programmes, developed in-house, to reliably quantify neovascularization of the retina and leakage, assess microaneurysm turnover in diabetic patients (RetmarkerDR® product), classify and quantify AMD lesions and disease activity in patients with AMD (RetmarkerAMD Research product) and perform segmentation of the retinal layers and quantify cystoid-like spaces on OCT.
Summary - Main Grading Activities
Diabetic Retinopathy (DR)
Age-related Macular Degeneration (AMD)
(CFP – Color Fundus Photography; FA – Fluorescein Angiography; ICG - Indocyanine Green Angiography; mfERG – multifocal Electroretinography; OCT – Optical Coherence Tomography.)
Grading of fundus images