Latest Ongoing Projects
Centre for Clinical Trials
A single arm, open-label, multicenter study evaluating the long-term safety and tolerability of 0.5mg fingolimod (FTY720) administered orally once daily in patients with relapsing forms of multiple sclerosis (Protocol CTFY720D2399) [more info]
Randomized, open label multi-center study comparing cabazitaxel at 25 mg/m2 in combination with prednisone every 3 weeks to Docexatel in combination with prednisone in patients with metastatic castration resistant prostate cancer not pre-treated with chemotherapy (Firstana) (Protocol EFC11784) [more info]
A 24-month, phase IIIb, open-label, single arm, multicenter study assessing the efficacy and safety of an individualized, stabilization criteria-driven PRN dosing regimen with 0.5-mg ranibizumab intravitreal injections applied as monotherapy in patients with visual impairment due to macular edema secondary to central retinal vein occlusion (CRVO) (Protocol CRFB002E2401) [more info]
Centre of Clinical Pharmacology
Elaboração e organização de um processo de Autorização de Introdução no Mercado (AIM) de cápsulas moles de 1000mg de ésteres etílicos do ácido omega – 3 90, compreendendo 460mg de éster etílico do ácido eicosapentanóico (EPA) e 380mg do éster etílico do ácido docosahexanóico (DHA). [more info]
Safety and efficacy of eslicarbazepine acetate (ESL) as adjunctive therapy for partial seizures in elderly patients. [more info]
Efficacy and safety of Eslicarbazepine acetate (BIA 2-093) as monotheraphy for patients with newly diagnosed partial-onset seizures: a double- blind, double-dummy, randomized, active-controlled, parallel- group, multicenter clinical study. [more info]
Centre of New Technologies for Medicine
Unveiling preclinical idiopathic macular hole formation: structural changes by high-definition optical coherence tomography and machine learning (PTDC/BBB-BMD/2739/2012) [more info]
Laser Guided Photocoagulation [more info]
Optical Modelling of the Human Retina in Health and Disease: from structure to function (PTDC/SAU-ENB/119132/2010) [more info]
Coimbra Coordinating Centre for Clinical Research
Pharmacokinetic assessment of ceftriaxone (Betasporina) or clavulanic acid or ceftriaxone plus clavulanic acid administered by the endovenous route (Protocol ATRAL/CFC/273/11) [more info]
Life style and food habits questionnaire in the Portuguese population aged 55 or more (Food Inquiry) [more info]
VitaminD3 – Omega3 – Home Exercise HeALTHy Ageing and Longevity Trial (DO-HEALTH) [more info]
Health Technology Assessment
Evaluation of therapeutic value, economic value and budget impact model for Zaltrap [more info]
Evaluation of therapeutic value, economic value and budget impact model for Lyxumia [more info]
Evaluation of economic value of Tepadina [more info]
Coimbra Ophthalmology Reading Centre
Validation of a Predictive Model to Estimate the Risk of Conversion to Clinically Significant Macular Edema and/or Vision Loss in Mild Nonproliferative Retinopathy in Diabetes Type 2 (Protocol nº PTDC/SAU-OSM/72635/2006) [more info]
Retinal Disease Screening System (RDSS) [more info]
Neurodegeneration as an early event in the pathogenesis of Diabetic Retinopathy: A multicentric, prospective, phase II-III, randomised controlled trial to assess the efficacy of neuroprotective drugs administered topically to prevent or arrest Diabetic Retinopathy (EUROCONDOR) (Protocol nº 4C-2011-02) [more info]