Rui Bernardes Director CNTM - Centre of New Technologies for Medicine

 

Personal data

Academic degrees

Participation in research projects

• Unveiling preclinical idiopathic macular hole formation: structural changes by high-definition optical coherence tomography and machine learning (PTDC/BBB-BMD/2739/2012) [more info]
• Optical Modelling of the Human Retina in Health and Disease: from structure to function (PTDC/SAU-ENB/119132/2010) [more info]
• 3D retinal vascular network from Optical Coherence Tomography data (PTDC/SAU-ENB/111139/2009) [more info]
• Correlation phenotype/genotype in diabetic retinopathy (Protocol CEC/120) (PTDC/SAU-OSM/103226/2008) [more info]
• Evaluation of blood-retinal barrier functional alterations by optical coherence tomography (PTDC/SAU-BEB/103151/2008) [more info]
• Retmarker - Critical Health / MA-Tracker [more info]
• Ver + Saúde [more info]
• Development of new methods of quantification and standardization of Fluorescein in ocular media [more info]
• Development and clinical applications of a system with adaptive optics for ocular tomography and high-resolution retinal imaging (PTDC/SAU-BEB/72220/2006) [more info]
• Validation of a predictive model to estimate the risk of conversion to clinically significant macular edema and/or vision loss in mild nonproliferative retinopathy in diabetes type 2 (PDTC/SAU-OSM/72635/2006) [more info]
• Clinical study to characterize early markers of choroidal neovascularization in fellow eyes of patients with Age Related Macular Degeneration (“AMD”) and Chorioretinal Neovascularization (“CNV”) in one eye [more info]
• Development of new methods of quantification and standardization of Fluorescein in ocular media [more info]
• Structure-function imaging for quantitive phenotyping or retinal degenerations (POSI/EEA-SRI/60716/2004) [more info]
• Functional Genomics of the Retina in Health and Disease (EVI-GENORET) [more info]
• Multi-Modality Medical Registration for Eye Diagnosis (POSI/SRI/ 45151/2002) [more info]
• Characterization of the mechanisms of resolution of diabetic macular edema after photocoagulation treatment with laser (POCTI/CBO/ 43061/2001) [more info]
• European Virtual Institute for Geometry Measurements [more info]
• Development of new technologies and instrumentation for clinical macular examination [more info]
• Prospective study of the initial changes occuring in the retinal microcirculation in diabetes by multimodal imaging of the eye fundus (POCTI/CBO/ 35866/1999) [more info]
• New Ocular Fluorometer [more info]
• Glaucoma Prevention by Computer Aided Diagnosis [more info]
• Kinetic and topographic vitreous fluorometry studies using a new high-resolution confocal optical system in health and diabetes [more info]

Prizes and awards

Publications

• Rodrigues P., Serranho P., Bernardes R. 3D Nonlinear Complex-Diffusion Filter on GPU. [more info]
• Serranho P., Guimarães P., Rodrigues P., Bernardes R. On the relevance of the 3D retinal vascular network from OCT data. [more info]
• Santos T., Ribeiro L., Lobo C., Bernardes R., Serranho P. Validation of the automatic identification of eyes with diabetic retinopathy by OCT. [more info]
• Rodrigues, P. & Bernardes, R. 3D Adaptive Nonlinear Complex-Diffusion Despeckling Filter. [more info]
• Guimarães, P.; Rodrigues, P.; Serranho, P. & Bernardes, R. 3D Retinal Vascular Network from Optical Coherence Tomography Data. [more info]
• Maduro, C.; Serranho, P.; Santos, T.; Rodrigues, P.; Cunha-Vaz, J. & Bernardes, R. OCT Noise Despeckling Using 3D Nonlinear Complex Diffusion Filter. [more info]
• Rodrigues P., Santos T., Pereira H., Figueira J., Bernardes R. Identification of Eyes at Risk of Developing Idiopathic Macular Holes by Support Vector Machines. [more info]
• Bernardes R., Serranho P., Santos T., Gonçalves V., Cunha-Vaz J. Optical Coherence Tomography: automatic retina classification through support vector machines. [more info]
• Serranho P., Morgado M., Bernardes R. Optical Coherence Tomography: a concept review. [more info]
• Cunha-Vaz J., Bernardes R., Santos T., Oliveira C., Lobo C., Pires I., Ribeiro L. Computer-Aided Detection of Diabetic Retinopathy Progression. [more info]
• Bernardes R., Cunha-Vaz J. Evaluation of the blood-retinal barrier with optical coherence tomography. [more info]
• Bernardes R., Cunha-Vaz J. (ed.) Biological and Medical Physics, Biomedical Engineering. Optical Coherence Tomography: A Clinical and Technical Update. [more info]
• Cunha-Vaz J., Bernardes R., Lobo C. Clinical Phenotypes of Diabetic Retinopathy. [more info]
• Serranho P., Maduro C., Santos T., Cunha-Vaz J., Bernardes R. Synthetic OCT data for image processing performance testing. [more info]
• Serranho P., Bernardes R., Maduro C., Santos T., Cunha-Vaz J.G. Synthetic Volume from Real Optical Coherence Tomography Data. [more info]
• Santos T., Santos A.R., Bernardes R,. Cunha-Vaz J.G. Poor Correlation Between PHP Measurements and Development of Choroidal Neovascularization in AMD Patients. [more info]
• Santos T., Bernardes R., Santos A., Cunha-Vaz J. Noninvasive Assessment of Blood-Retinal Barrier Function by High-Definition Optical Coherence Tomography. [more info]
• Santos A.R., Cachulo M.L., Fonseca P., Nunes S., Bernardes R., Cunha-Vaz J., Silva R. Risk Factors for the Development of Choroidal Neovascularization in the Fellow Eye of Patients with Age Related Macular Degeneration - A Three Year Follow-up Study. [more info]
• Maduro C., Serranho P., Bernardes R., Cunha-Vaz J.G. Qualitative And Quantitative Analysis Of OCT Filtering. [more info]
• Maduro C., Bernardes R., Serranho P., Santos T., Cunha-Vaz J. OCT noise despeckling using 3D nonlinear complex diffusion filter. [more info]
• Ribeiro, L.; Bernardes, R. & Cunha-Vaz, J. Computer-aided Analysis of Fundus Photographs. [more info]
• Bernardes R., Serranho P., Rodrigues P., Gonçalves V., Cunha-Vaz J. Blood-retinal barrier function status from OCT data. [more info]
• Serranho P., Maduro C., Santos T., Cunha-Vaz J., Bernardes R., Araujo A., Barbeiro S. Ocular fundus imaging: From structure to function. [more info]
• Silva R., Cachulo M., Fonseca P., Bernardes R., Nunes S., Vilhena N. & Faria de Abreu J. Age-related macular degeneration and risk factors for the development of choroidal neovascularisation in the fellow eye: a 3-year follow-up study [more info]
• Bernardes R., Serranho P., Lobo C. Digital Ocular Fundus Imaging: A Review [more info]
• Serranho P., Maduro C., Santos T., Cunha-Vaz J., Bernardes R. Synthetic OCT data for image processing performance testing [more info]
• Bernardes R. Optical Coherence Tomography: health information embedded on OCT signal statistics [more info]
• Bernardes R., Santos T., Serranho P., Lobo C., Cunha-Vaz J. Noninvasive Evaluation of Retinal Leakage Using Optical Coherence Tomography [more info]
• Cunha-Vaz J., Bernardes R., Lobo C. Blood-retinal barrier [more info]
• Cachulo L., Silva R., Fonseca P., Pires I., Carvajal-Gonzalez S., Bernardes R., Cunha-Vaz J. Early Markers of Choroidal Neovascularization in the Fellow Eye of Patients with Unilateral Exudative Age-Related Macular Degeneration [more info]
• Bernardes R., Maduro C., Serranho P., Lobo C., Cunha-Vaz J. Optical coherence tomography speckle denoising. [more info]
• Cunha-Vaz J., Bernardes R., Lobo C. Blood-retinal barrier. [more info]
• Nunes S., Pereira I., Santos A., Bernardes R., Cunha-Vaz J. Retinal thickness with HD-OCT is not a surrogate outcome for visual acuity changes in diabetic macular edema. [more info]
• Santos T., Bernardes R., Santos A., Cunha-Vaz J. Noninvasive Assessment of Blood-Retinal Barrier Function by High-Definition Optical Coherence Tomography. [more info]
• Maduro C., Bernardes R., Serranho P., Santos T., Cunha-Vaz J. OCT noise despeckling using a 3D nonlinear complex diffusion filter. [more info]
• Bernardes R., Maduro C., Serranho P., Araújo A., Barbeiro S., Cunha-Vaz J. Improved adaptive complex diffusion despeckling filter [more info]
• Nunes S., Pereira I., Santos A., Bernardes R., Cunha-Vaz J. Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME. [more info]
• Bernardes R., Nunes S., Pereira I., Lobo C., Cunha-Vaz J. Semi-automated assessment of microaneurysm formation rate from color fundus photographs in patients with mild NPDR. [more info]
• Bernardes R., Santos T., Cunha-Vaz J. High-definition Fourier domain OCT: non-invasive assessment of BRB changes. [more info]
• Nunes S., Bernardes R., Lobo C., Cunha-Vaz J. Validation of a predictive model for diabetic retinopathy progression in type-2 diabetic patients with mild nonproliferative diabetic retinopathy. [more info]
• Bernardes R., Santos T., Cunha-Vaz J. Evaluation of blood-retinal barrier function from fourier domain high definition optical coherence tomography. [more info]
• Nunes S., Pires I., Rosa A., Duarte L., Bernardes R., Cunha-Vaz J. Microaneurysm Turnover Is a Biomarker for Diabetic Retinopathy Progression to Clinically Significant Macular Edema: Findings for Type 2 Diabetics with Nonproliferative Retinopathy. [more info]
• Bernardes R., Nunes S., Pereira I., Torrent T., Rosa A., Coelho D., Cunha-Vaz J. Computer-assisted microaneurysm turnover in the early stages of diabetic retinopathy. [more info]
• Pires I., Duarte L., Nunes S., Pereira I., Bernardes R., Cunha-Vaz J. Microaneurysms Formation Rate as a Predictor of DR Progression to CSME Needing Photocoagulation in Nonproliferative Retinopathy in Diabetes Type 2. [more info]
• Pereira I., Nunes S., Ribeiro M., Bernardes R., Cunha-Vaz J. Risk markers for progression of mild nonproliferative retinopathy to clinically significant macular edema in type 2 diabetic patient. [more info]
• Bernardes R., Cunha-Vaz J. New developments in OCT evaluations. [more info]
• Bernardes R., Cunha-Vaz J. Retinal thickness vs. retinal sensitivity at the central human macula. [more info]
• Bernardes R., Lobo C., Cunha-Vaz J. Multimodal mapping of the macula. [more info]
• Bernardes R. Desenvolvimento de Novas Metodologias para o Mapeamento Multimodal da Mácula [more info]
• Bernardes R., Cunha-Vaz J. Perspectives for multimodal imaging of the retina in disease. [more info]
• Bernardes R., Santos T., Cunha-Vaz J. Increased-Resolution OCT Thickness Mapping of the Human Macula: A Statistically Based Registration. [more info]
• Dijk H., Kok P., Abràmoff M., Schlingemann R., Bernardes R., Verbraak F. The sensitivity of OCT in the diagnosis of clinically significant macular edema. [more info]
• Santos T., Bernardes R., Baptista P., Schwartz A., Carter W., Cunha-Vaz J. Quantitative fluorescein angiograms. [more info]
• Bernardes R. Instrumentation adaptation for quantitative fluorescein angiograms. [more info]
• Baptista P., Ferreira J., Bernardes R., Dias J., Cunha-Vaz J. Computational Modelling of Objects Represented in Images [more info]
• Castelo-Branco M., Mendes M., Sebastião A., Reis A., Soares M., Saraiva J., Bernardes R., Flores R., Pérez-Jurado L., Silva E. Visual phenotype in Williams-Beuren syndrome challenges magnocellular theories explaining human neurodevelopmental visual cortical disorders. [more info]
• Bernardes R., Santos T., Cunha-Vaz J. Increased Resolution Macular Thickness Mapping by OCT. [more info]
• Nunes S., Baptista P., Bernardes R., Cunha-Vaz J. Comparison of retinal thickness measurements obtained by Retinal Thickness Analyzer (RTA II) and Optical Coherence Tomography (Stratus OCT) in healthy subjects. [more info]
• Bernardes R. Retinal Leakage Analysis. [more info]
• Baptista P., Bernardes R., Ferreira J., Dias J., Cunha-Vaz J. Multimodal Macula Mapping: study for rigid, perspective and deformable image registration. [more info]
• Ferreira J., Bernardes R., Baptista P., Cunha-Vaz J. Earmarking retinal changes in a sequence of digital color fundus photographs. [more info]
• Bernardes R., Ferreira J., Baptista P., Sebastião A., Dias J., Cunha-Vaz J. Distortion free registration between multifocal ERG and retinal leakage analyzer. [more info]
• Bernardes R., Baptista P., Dias J., Cunha-Vaz J. Multimodal Functional and Morphological Nonrigid Image Registration. [more info]
• Cunha-Vaz J., Bernardes R. Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes. [more info]
• Bernardes R., Dias J., Cunha-Vaz J. Mapping the Human Blood-Retinal Barrier Function. [more info]
• Bernardes R., Figueira J., Lobo C., Cunha-Vaz J. Mapping Clinically Significant Diabetic Macular Edema. Comparison Between Stereofundus Photography, RTA and OCT. [more info]
• Cunha-Vaz J., Bernardes R. Multimodal Macula Mapping: Characterization of Phenotypes of Diabetic Retinopathy. [more info]
• Lobo C., Faria P., Soares M., Bernardes R., Cunha-Vaz J. Macular alterations after small incision cataract surgery. [more info]
• Lobo C., Bernardes R., Figueira J., Faria de Abreu J., Cunha-Vaz J. Three-year Follow-up Study of Blood-Retinal Barrier and Retinal Thickness Alterations in Patients with Type 2 Diabetes Mellitus and Mild Nonproliferative Diabetic Retinopathy. [more info]
• Ludovico J., Bernardes R., Pires I., Figueira J., Lobo C., Cunha-Vaz J. Alterations of retinal capillary blood flow in preclinical retinopathy in subjects with type 2 diabetes. [more info]
• Bernardes R., Cunha-Vaz J. Interpretation of Objectively Acquired Retinal Thickness Values. [more info]
• Bernardes R., Lobo C., Dias J., Cunha-Vaz J. New instrumentation for blood-retinal barrier permeability analysis. [more info]
• Bernardes R., Lobo C., Cunha-Vaz J. Multimodal Macula Mapping: A new approach to study diseases of the Macula. [more info]
• Pires I., Bernardes R., Lobo C., Soares M., Cunha-Vaz J. Retinal Thickness in Eyes With Mild Nonproliferative Retinopathy in Patients With Type 2 Diabetes Mellitus: Comparison of Measurements Obtained by Retinal Thickness Analysis and Optical Coherence Tomography. [more info]
• Cunha-Vaz J., Bernardes R., Lobo C., Faria de Abreu J. Measurements of Retinal Thickness for Evaluation of Macular Edema. [more info]
• Ludovico J., Pires I., Bernardes R., Lobo C., Cunha-Vaz, J. Reproducibility of HRF. [more info]
• Lobo C., Bernardes R., Faria de Abreu J., Cunha-Vaz J. One-year follow-up of blood retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative retinopathy [more info]
• Bernardes R., Lobo C., Cunha-Vaz J. Measuring retinal fluorescein leakage into the human vitreous with a modified confocal scanning laser ophthalmoscope. [more info]
• Lobo C., Bernardes R., Cunha-Vaz J. Alterations of the blood-retinal barrier and retinal thickness in preclinical retinopathy in subjects with type 2 diabetes. [more info]
• Lobo C., Cunha-Vaz, J., Bernardes R. Retinal leakage analyzer. [more info]
• Bernardes R., Isidoro J., Simões P., Lobo C., Cunha-Vaz J. Measuring retinal fluorescein leakage into the human vitreous with a modified confocal scanning laser ophthalmoscope. [more info]
• Lobo C., Bernardes R., Faria de Abreu J., Cunha-Vaz J. Novel imaging techniques for diabetic macular edema. [more info]
• Lobo C., Bernardes R., Santos F., Cunha-Vaz J. Mapping retinal fluorescein leakage with confocal scanning laser fluorometry of the human vitreous. [more info]